She is perhaps best known for her singles "Pop the Glock", as well as "ADD SUV (feat. Pharell Williams)", "Hot Chick", "MC's Can Kiss", and "Tthhee Ppaarrttyy", her 2007 collaboration with labelmates Justice. Her recent live performances have been compared to other artists in the Andy Warhol art movement.

Her long awaited debut album, Sex Dreams and Denim Jeans was released in Europe through Ed Banger Records on June 11, 2010 and in the US by Elektra Records on June 22, 2010.

Anna-Catherine Hartley was born in Florida but moved to Hong Kong when she was four years old due to her father's work. She lived in Hong Kong for most of her childhood, and was greatly influenced by the city. Uffie's name comes from the French words Un Oeuf (which means "an egg"), a nickname her father gave her as a child for being so rowdy. Her family once intended to spend a year sailing but a typhoon struck and the family had to abandon ship in the Philippines. In her teens, Hartley later moved with her mother to Fort Lauderdale and Miami, but at age 15 relocated to Paris with her father.[citation needed]

Once moving to France, she realized that she greatly preferred the European and French lifestyle over the American, and she has lived there since. Hartley originally studied fashion in Paris and attended the International School of Paris on the famous Rue de Passy, but when a music offer came along, she dropped out of school because it was "a once in a lifetime opportunity" and signed with Ed Banger Records in early 2006.

Uffie had booked DJ Feadz for a party she was organizing, and the two began a relationship. In a 2008 interview, Uffie explained her relationship status. She and Feadz had broken up earlier that year. Uffie then began dating graffiti artist André Saraiva and the two were briefly married in August 2008 but were divorced over the summer in 2009. Their daughter Henrietta was born in October 2009.

In early 2005, DJ Feadz, who was Uffie's boyfriend at the time convinced her to provide vocals on his track "Uffie & Me" for his EP Forward 4, which was when she began to develop an interest in making music. Later that year she wrote and recorded "Pop the Glock", which was produced by Feadz and began to shop the demo around to various record labels. Her first single, "Pop the Glock" was released in 2006 and is one of the most successful songs in the early underground electronic music scene around the early 2000s. "Pop the Glock" became her first single and was given a limited promo release on Arcade Mode in January 2006. Busy P, the owner of Ed Banger Records heard the single and quickly signed both Uffie and Feadz to the label. "Pop the Glock" and its B-side "Ready to Uff" were both given an official release titled, Pop the Glock/Ready to Uff on February 27, 2006 through Ed Banger Records. Both songs contained elements of electro and rap. The release also featured a remix by SebastiAn.

In February 2007, the song "Dismissed" was included on Ed Rec Vol. 2, an Ed Banger Records label compilation. Two more new tracks from Uffie, "Hot Chick" and "In Charge" were first proliferated through audioblogs in July 2006.[citation needed] Then in November, they were released together on her EP Hot Chick/In Charge on Ed Banger Records. In June 2007, the EP, Suited and Looted was released through Ed Banger Records. The release included the single "First Love" and "Brand New Car". Uffie and electronic duo Crystal Castles worked together on the track, "Make It Hott", although it was never officially released, it can be found through various audioblogs. Also in 2007, Uffie also collaborated with labelmates Justice for their 2007 debut, †, on a song entitled "Tthhee Ppaarrttyy".

In Spring of 2008 Uffie was Married to the Mob's exclusive model. Next, Uffie contributed her new song "Robot Oeuf" to Ed Rec Vol. 3, which was released on May 26, 2008. In late 2008, she worked with Mr. Oizo on the track "Steroids", which was released on Mr. Oizo's album Lambs Anger. A remix of "Steroids" was also included in Mr. Oizo's EP Pourriture. It was announced in early 2009, that her track "Robot Oeuf" would be included in the soundtrack to Pedro Almodovar's Spanish film Broken Embraces, starring Penelope Cruz.

Around this time, the music she was making was primarily for dance clubs/raves and was based around the idea of breaking away from society and doing whatever makes you happy, even if most others disapprove. Her music style has been described as being "often performed in a wannabe English accent" with "a deliberately staid anti-flow delivery that walks a fine line between electro and nu-skool rap."

Her record label, Ed Banger Records first stated in late 2006 that her debut album would be released 'mid-to-late 2007', then 'sometime in 2008'. Hectic traveling and touring schedules, her marriage and divorce, news of her pregnancy and growing as an artist delayed the release of her debut album, entitledSex Dreams and Denim Jeans which was released June 15, 2010 in Europe and June 22, 2010 in the United States. In 2009, Uffie gave birth to her first child, a girl, whom she named Henrietta, and also went through a divorce. After quite a stressful, hectic year she took a brief hiatus, which gave her time to find herself as artist and finally finish her full-length debut album.